In the recent study and research done by the Researchers, Federal University of Sao Paulo (UNIFESP) and the Federal University of Para (UFPA) in Brazil identified that the compounds found in turmeric can help to prevent and treat stomach cancer. As the scientist claim that they have recognized possible therapeutic effects of curcumin – the yellow powder derived from the roots of the turmeric plant.
Compounds such as cholecalciferol which is a form of vitamin D, resveratrol (a polyphenol) and quercetin can prevent stomach cancer because they are natural regulators of histone activity. Histones are proteins in cell nuclei that organize the DNA double helix into structural units called nucleosomes.
Researchers have studied the histone acetylation patterns in stomach cell samples from healthy individuals and patients diagnosed with stomach cancer.
Scientist found that the cells from the stomach of the cancer patient displayed adjustments in the example of articulation of histone acetyltransferases (HATs) and histone deacetylases (HDACs). These modifications are epigenetic and affect the structure and respectability of the genome in numerous tumours, including stomach malignant growth.
With the curcumin compound and other compounds like cholecalciferol, resveratrol (present mainly in grape seeds and red wine), quercetin (abundant in apples, broccoli and onions), garcinol (isolated from the bark of the kokum tree, Garcinia indica), and sodium butyrate (produced by gut bacteria via fermentation of dietary fiber). Were also found to play a vital role in modulating the histone activity which helps in preventing the stomach cancer.
” Danielle Queiroz Calcagno, a professor at UFPA said “We undertook a vast review of the scientific literature on all nutrients and bioactive compounds with the potential to prevent or treat stomach cancer and found that curcumin is one of them”
‘The found compound in turmeric can favour for the activation or repression of genes involved in the development of stomach cancer by promoting or inhibiting histone acetylation’, added Calcagno. ‘The found compound in turmeric can favour for the activation or repression of genes involved in the development of stomach cancer by promoting or inhibiting histone acetylation’, added Calcagno.